Health Research Access to Personal Confidential Data in England and Wales: Assessing any gap in public attitude between preferable and acceptable models of consent

England and Wales are moving toward a model of ‘opt out’ for use of personal confidential data in health research. Existing research does not make clear how acceptable this move is to the public. While people are typically supportive of health research, when asked to describe the ideal level of control there is a marked lack of consensus over the preferred model of consent (e.g. explicit consent, opt out etc.). This study sought to investigate a relatively unexplored difference between the consent model that people prefer and that which they are willing to accept. It also sought to explore any reasons for such acceptance. A mixed methods approach was used to gather data, incorporating a structured questionnaire and in-depth focus group discussions led by an external facilitator. The sampling strategy was designed to recruit people with different involvement in the NHS but typically with experience of NHS services. Three separate focus groups were carried out over three consecutive days. The central finding is that people are typically willing to accept models of consent other than that which they would prefer. Such acceptance is typically conditional upon a number of factors, including: security and confidentiality, no inappropriate commercialisation or detrimental use, transparency, independent overview, the ability to object to any processing considered to be inappropriate or particularly sensitive. This study suggests that most people would find research use without the possibility of objection to be unacceptable. However, the study also suggests that people who would prefer to be asked explicitly before data were used for purposes beyond direct care may be willing to accept an opt out model of consent if the reasons for not seeking explicit consent are accessible to them and they trust that data is only going to be used under conditions, and with safeguards, that they would consider to be acceptable even if not preferable

The Transition between Nonorthogonal Polarization Modes in PSR B2016+28 at 1404 MHz

Polarization observations of the radio emission from PSR B2016+28 at 1404 MHz reveal properties that are consistent with two, very different, interpretations of the pulsar's viewing geometry. The pulsar's average polarization properties show a rapid change in position angle (PA) near the pulse center, suggesting that the observer's sightline nearly intersects the star's magnetic pole. But single pulse, polarization observations of the pulsar show nearly orthogonal modes of polarization following relatively flat and parallel PA trajectories across the pulse, suggesting that the sightline is far from the pole. Additionally, PA histograms reveal a "modal connecting bridge", of unknown origin, joining the modal PA trajectories over much of the pulse and following the rapid PA change shown in the average data. The nonorthogonality of polarization modes is incorporated in a statistical model of radio polarization to account for the deviations from mode orthogonality that are observed in the pulsar. The model is used to interpret the rapid PA change and modal connecting bridge as a longitudinally-resolved transition between modes of nonorthogonal polarization. Thus, the modal PA trajectories are argued to reflect the pulsar's true viewing geometry. This interpretation is consistent with the pulsar's morphological classification, preserves the Radhakrishnan & Cooke model of pulsar radio emission, and avoids the complication that the modal connecting bridge might be produced by some other emission mechanism. The statistical model's ability to simulate the rich variety of polarization properties observed in the emission lends additional support to the model's applicability and its underlying assumption that the polarization modes occur simultaneously.Comment: Accepted for publication in Ap

Prostatic Acid Phosphatase Is Expressed in Peptidergic and Nonpeptidergic Nociceptive Neurons of Mice and Rats

Thiamine monophosphatase (TMPase, also known as Fluoride-resistant acid phosphatase or FRAP) is a classic histochemical marker of small- to medium-diameter dorsal root ganglia (DRG) neurons and has primarily been studied in the rat. Previously, we found that TMPase was molecularly identical to Prostatic acid phosphatase (PAP) using mice. In addition, PAP was expressed in a majority of nonpeptidergic, isolectin B4-binding (IB4+) nociceptive neurons and a subset of peptidergic, calcitonin gene-related peptide-containing (CGRP+) nociceptive neurons. At the time, we were unable to determine if PAP was present in rat DRG neurons because the antibody we used did not cross-react with PAP in rat tissues. In our present study, we generated a chicken polyclonal antibody against the secretory isoform of mouse PAP. This antibody detects mouse, rat and human PAP protein on western blots. Additionally, this antibody detects PAP in mouse and rat small- to medium-diameter DRG neurons and axon terminals in lamina II of spinal cord. In the rat, 92.5% of all PAP+ cells bind the nonpeptidergic marker IB4 and 31.8% of all PAP+ cells contain the peptidergic marker CGRP. Although PAP is found in peptidergic and nonpeptidergic neurons of mice and rats, the percentage of PAP+ neurons that express these markers differs between species. Moreover, PAP+ axon terminals in the rat partially overlap with Protein kinase Cγ (PKCγ+) interneurons in dorsal spinal cord whereas PAP+ axon terminals in the mouse terminate dorsal to PKCγ+ interneurons. Collectively, our studies highlight similarities and differences in PAP localization within nociceptive neurons of mice and rats